Clozapine: Selective Labeling of Sites Resembling 5HT6 Serotonin Receptors May Reflect Psychoactive Profile
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چکیده
منابع مشابه
Serotonin receptor affinities of psychoactive phenalkylamine analogues.
Employing a rat fundus model, the serotonin (5-HT) receptor affinities of 45 phenalkylamine analogues were determined. Phenethylamine and phenylisopropylamine possess relatively low receptor affinities; in general, mono-, di-, and trimethoxylation enhance affinity. Of the disubstituted compounds, methoxyl groups at the 2 and 5 positions are optimal for imparting a high affinity. 4-Methylation, ...
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Heparan sulfate proteoglycans are key regulators of complex molecular networks due to the interaction of their sugar chains with a large number of partner proteins, which in humans number more than 200 (Ori, A., Wilkinson, M. C., and Fernig, D. G. (2008) The heparanome and regulation of cell function: structures, functions and challenges. Front. Biosci. 13, 4309-4338). We developed a method to ...
متن کاملSerotonin receptors.
2. Classification of Serotonin Receptors 1625 2.1. Gq/11-Coupled Receptor Types 1626 2.1.1. The 5-HT2A Receptor 1626 2.1.2. The 5-HT2B Receptor 1627 2.1.3. The 5-HT2C Receptor 1628 2.2. Gs-Coupled Receptor Types 1628 2.2.1. The 5-HT4 Receptor 1629 2.2.2. The 5-HT6 Receptor 1629 2.2.3. The 5-HT7 Receptor 1629 2.3. Gi/o-Coupled Receptor Types 1630 2.3.1. The 5-HT1A Receptor 1630 2.3.2. The 5-HT1B...
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Selective T-cell unresponsiveness, as measured by interleukin 2 (IL-2) synthesis upon challenge with antigen, was induced in SJL mice by ovalbumin (OVA) in incomplete or complete Freund's adjuvant administered i.p. or s.c. Ten days later, the mice were given booster injections of 100 micrograms of OVA/complete Freund's adjuvant. On day 20, lymph node and spleen cells were challenged in vitro wi...
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Professional deep-water divers exposed to high pressure (HP) above 1.1 MPa suffer from High Pressure Neurological Syndrome (HPNS), which is associated with CNS hyperexcitability. We have previously reported that HP augments N-methyl-D-aspartate receptor (NMDAR) synaptic responses, increases neuronal excitability, and potentially causes irreversible neuronal damage. We now report that HP (10.1 M...
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ژورنال
عنوان ژورنال: Molecular Medicine
سال: 1995
ISSN: 1076-1551,1528-3658
DOI: 10.1007/bf03401577